![]() Here, we demonstrate that mRNA localization and local translation of the RhoGAP ARHGAP11A in the basal endfeet of RGCs control their morphology and mediate neuronal positioning. Yet the mechanisms by which subcellular RGC compartments accomplish their diverse functions are poorly understood. These features are especially prominent in radial glial cells (RGCs), which are neural and glial precursors of the developing cerebral cortex and scaffolds for migrating neurons. ![]() MRNA localization and local translation enable exquisite spatial and temporal control of gene expression, particularly in polarized, elongated cells.
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